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Intraduodenal cholecystokinin octapeptide (CCK-8) can stimulate pancreatic secretion in the calf

Authors :
Zabielski, Romuald
Onaga, Takenori
Mineo, Hitoshi
Kato, Seiyu
Pierzynowski, Stefan G.
Source :
International Journal of Pancreatology; June 1995, Vol. 17 Issue: 3 p271-278, 8p
Publication Year :
1995

Abstract

The effect of CCK-8 administered into the duodenal lumen and into the systemic blood on pancreatic, secretion and duodenal migrating myoelectric complex (MMC) was studied in four calves. Simultaneous MMC recordings and collections of pancreatic juice were performed on valves that had been fasted overnight. Intraduodenal (o, 100, and 300 pmol/kg body wt) and intravenous (0, 30, and 100/pmol kg) infusions of CCK-8 were made for 5 min during the no spiking activity (NSA) phase of duodenal MMC associated with a nadir of periodic pancreatic secretion. CCK-8 was also administered during continuous atropine infusion (5 µg/kg/min). Both intraduodenal and intravenous infusions of CCK-8 resulted in marked pancreatic responses in juice outflow, bicarbonate output, and protein output. Atropine decreased pancreatic response (protein output) to intravenous CCK-8 and markedly inhibited the response (juice flow, bicarbonate, and protein output) to intraduodenal CCK-8. Infusions of CCK-8 did not affect the duration of MMC in the duodenum. Plasma CCK increased significantly after intravenous infusion, but remained unchanged after intraduodenal infusion. In conclusion, CCK-8 can stimulate pancreatic secretion from the duodenal lumen, possibly via a cholinergic mechanism in the calf.

Details

Language :
English
ISSN :
01694197 and 23635134
Volume :
17
Issue :
3
Database :
Supplemental Index
Journal :
International Journal of Pancreatology
Publication Type :
Periodical
Accession number :
ejs62534857
Full Text :
https://doi.org/10.1007/BF02785824