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Using a combination of peripapillary atrophy area and choroidal thickness for the prediction of different types of myopic maculopathy

Authors :
He, Jiangnan
Ye, Luyao
Chu, Chen
Chen, Qiuying
Sun, Dandan
Xie, Jiamin
Hu, Guangyi
Shi, Ya
Fan, Ying
Zhu, Jianfeng
Xu, Xun
He, Jia
Source :
Eye; September 2023, Vol. 37 Issue: 13 p2801-2809, 9p
Publication Year :
2023

Abstract

Purpose: To analyse the topographic characteristics in macular choroidal thickness (mChT) and ocular biometry in myopic maculopathy and to explore the potential cut-off value for prediction of myopic maculopathy (MM). Methods: All participants underwent detailed ocular examinations. MM was subdivided into thin choroid, Bruch’s membrane (BM) defects, choroidal neovascularization (CNV), and myopic tractional maculopathy (MTM) according to OCT-based classification system. Peripapillary atrophy area (PPA), tilt ratio, torsion, and mChT were individually measured. Results: A total of 1947 participants were included. In multivariate logistics models, older age, longer axial length, larger PPA area, and thinner average mChT were more likely to have MM and different type of MM. Female participants were more likely to have MM and BM defects. A lower tilt ratio was more likely to be associated with CNV and MTM. The area under the curve (AUC) of single tilt ratio, PPA area, torsion, and topographic of mChT for MM, thin choroid, BM Defects, CNV, and MTM were 0.6581 to 0.9423, 0.6564 to 0.9335, 0.6120 to 0.9554, 0.5734 to 0.9312, 0.6415 to 0.9382, respectively. After combining PPA area and average mChT for predicting MM, thin choroid, BM defects, CNV, and MTM, the AUC of the combination were 0.9678, 0.9279, 0.9531, 0.9213, 0.9317, respectively. Conclusion: Progressive and continuous PPA area expanding and thin choroid play a role in the development of myopic maculopathy. The present study showed that a combination of peripapillary atrophy area and the choroidal thickness could be used to predict MM and each type of MM.

Details

Language :
English
ISSN :
0950222X and 14765454
Volume :
37
Issue :
13
Database :
Supplemental Index
Journal :
Eye
Publication Type :
Periodical
Accession number :
ejs62456168
Full Text :
https://doi.org/10.1038/s41433-023-02423-0