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Efficacy and safety of colesevelam for the treatment of bile acid diarrhoea: a double-blind, randomised, placebo-controlled, phase 4 clinical trial
- Source :
- The Lancet Gastroenterology & Hepatology; April 2023, Vol. 8 Issue: 4 p321-331, 11p
- Publication Year :
- 2023
-
Abstract
- Bile acid diarrhoea is a common but overlooked cause of chronic watery diarrhoea. Plasma 7α-hydroxy-4-cholesten-3-one (C4) is an alternative to the gold standard tauroselcholic [75Se] acid (SeHCAT) test. Low-certainty evidence supports sequestrant treatment, including colesevelam. We aimed to determine the efficacy and safety of colesevelam in bile acid diarrhoea.
Details
- Language :
- English
- ISSN :
- 24681253
- Volume :
- 8
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- The Lancet Gastroenterology & Hepatology
- Publication Type :
- Periodical
- Accession number :
- ejs62450269
- Full Text :
- https://doi.org/10.1016/S2468-1253(22)00401-0