Significant association between FGFR1mutation frequency and age in central giant cell granuloma

Central giant cell granulomas (CGCG) are rare intraosseous osteolytic lesions of uncertain aetiology. Despite the benign nature of this neoplasia, the lesions can rapidly grow and become large, painful, invasive, and destructive. The identification of molecular drivers could help in the selection of targeted therapies for specific cases. TRPV4, KRASand FGFR1mutations have been associated with these lesions but no correlation between the mutations and patient features was observed so far.