A Shared Genetic Signature for Common Chronic Pain Conditions and its Impact on Biopsychosocial Traits

•Phenome-wide association analyses reveal shared genetic causal effects across 8 chronic pain types.•Across >1,400 other complex traits, a small proportion (82) were affected by chronic pain.•410 and 78 traits contributed to an increased or decreased risk of chronic pain (respectively).•These genetically supported risk & protective factors enhance translationally targeted studies.•The results also provide corroborating evidence for particular treatment & prevention strategies.