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SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome
- Source :
- Heart Rhythm O2; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- Long QT syndrome (LQTS) stems from pathogenic variants in KCNQ1(LQT1), KCNH2(LQT2), or SCN5A(LQT3) and is characterized by action potential duration (APD) prolongation. Inhibition of serum and glucocorticoid regulated kinase-1 (SGK1) is proposed as a novel therapeutic for LQTS.
Details
- Language :
- English
- ISSN :
- 26665018
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Heart Rhythm O2
- Publication Type :
- Periodical
- Accession number :
- ejs62266851
- Full Text :
- https://doi.org/10.1016/j.hroo.2023.02.003