Preventive treatment of unruptured intracranial aneurysms in adult patients with sickle cell anemia: a cohort study

•Intracranial aneurysms are diagnosed in up to 9% of patients with sickle cell anemia, while consensual approaches to treatment of unruptured intracranial aneurysms in this population are still lacking.•A standardized hematological preparation protocol was undertaken before each aneurysm treatment.•Overall, endovascular and surgical treatment seems safe and effective: successful treatment was documented in 95% of aneurysms, while all 6 post-procedural complications were transitory or reversible, without residual deficits at one-year follow-up.•We suggest using stenting as a last therapeutic resort due to the potential high rate of ischemic complications in this population.