Immune Dysregulation in TRD: Precision Approaches to Treatment Selection and Development of Novel Treatments

Due to the link between immune dysfunction and treatment resistant depression (TRD) and the overwhelming evidence that immune dysregulation and major depressive disorder (MDD) are associated with each other, using immune profiles to identify biological distinct subgroup may be the step forward to understanding MDD and TRD. This report aims to briefly review the role of inflammation in the pathophysiology of depression (and TRD in particular), the role of immune dysfunction to guide precision medicine, tools used to understand immune function, and novel statistical techniques that may allow for the use of immunological data to usher an era of precision medicine for psychiatry.