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Lineage switching of the cellular distribution of BRAFV600Ein multisystem Langerhans cell histiocytosis

Authors :
Milne, Paul
Bomken, Simon
Slater, Olga
Kumar, Ashish
Nelson, Adam
Roy, Somak
Velazquez, Jessica
Mankad, Kshitij
Nicholson, James
Yeomanson, Dan
Grundy, Richard
Kamal, Ahmed
Penn, Anthony
Pears, Jane
Millen, Gerard
Morland, Bruce
Hayden, James
Lam, Jason
Madkhali, Maymoon
MacDonald, Jamie
Singh, Preeti
Pagan, Sarah
Rodriguez-Galindo, Carlos
Minkov, Milen
Donadieu, Jean
Picarsic, Jennifer
Allen, Carl
Bigley, Venetia
Collin, Matthew
Source :
Blood Advances; May 2023, Vol. 7 Issue: 10 p2171-2176, 6p
Publication Year :
2023

Abstract

•BRAFV600Ealleles are mainly found in myeloid cells at diagnosis of multisystem LCH.•After more than 2 years, T cells account for 85% of persistent BRAFV600Emutation detected in peripheral blood mononuclear cells.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
7
Issue :
10
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs62145969
Full Text :
https://doi.org/10.1182/bloodadvances.2021006732