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Successful Treatment of T‐cell Post‐Transplant Lymphoproliferative Disorder with the Retinoid Analog Bexarotene

Authors :
Tsai, Donald E.
Aqui, Nicole A.
Vogl, Dan T.
Bloom, Roy D.
Schuster, Stephen J.
Nasta, Sunita D.
Mariusz, A.
Source :
American journal of transplantation; August 2005, Vol. 5 Issue: 8 p2070-2073, 4p
Publication Year :
2005

Abstract

T‐cell post‐transplant lymphoproliferative disorder (PTLD) is a rare life threatening complication of organ transplantation. It is usually resistant to treatment with reduction in immunosuppression or chemotherapy and carries a poor prognosis. We report on a combined kidney and pancreas transplant patient with Epstein–Barr virus (EBV) positive T‐cell PTLD that had recurred after chemotherapy and reduction in immunosuppression. The patient was successfully treated with bexarotene, a novel synthetic retinoid analog, achieving a complete clinical response. Bexarotene may be a promising treatment for T‐cell PTLD.

Details

Language :
English
ISSN :
16006135 and 16006143
Volume :
5
Issue :
8
Database :
Supplemental Index
Journal :
American journal of transplantation
Publication Type :
Periodical
Accession number :
ejs62083898
Full Text :
https://doi.org/10.1111/j.1600-6143.2005.00948.x