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Successful Treatment of T‐cell Post‐Transplant Lymphoproliferative Disorder with the Retinoid Analog Bexarotene
- Source :
- American journal of transplantation; August 2005, Vol. 5 Issue: 8 p2070-2073, 4p
- Publication Year :
- 2005
-
Abstract
- T‐cell post‐transplant lymphoproliferative disorder (PTLD) is a rare life threatening complication of organ transplantation. It is usually resistant to treatment with reduction in immunosuppression or chemotherapy and carries a poor prognosis. We report on a combined kidney and pancreas transplant patient with Epstein–Barr virus (EBV) positive T‐cell PTLD that had recurred after chemotherapy and reduction in immunosuppression. The patient was successfully treated with bexarotene, a novel synthetic retinoid analog, achieving a complete clinical response. Bexarotene may be a promising treatment for T‐cell PTLD.
Details
- Language :
- English
- ISSN :
- 16006135 and 16006143
- Volume :
- 5
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- American journal of transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs62083898
- Full Text :
- https://doi.org/10.1111/j.1600-6143.2005.00948.x