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Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway
- Source :
- Journal of Thrombosis and Haemostasis; January 2023, Vol. 21 Issue: 1 p117-132, 16p
- Publication Year :
- 2023
-
Abstract
- Trimethylamine N-oxide (TMAO), a gut microbe–generated metabolite, elicits thrombotic events by enhancing platelet reactivity; however, no studies have reported the effects of TMAO on the metabolism of and response to clopidogrel.
Details
- Language :
- English
- ISSN :
- 15387933 and 15387836
- Volume :
- 21
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Thrombosis and Haemostasis
- Publication Type :
- Periodical
- Accession number :
- ejs62069779
- Full Text :
- https://doi.org/10.1016/j.jtha.2022.10.010