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Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke

Authors :
Mertens, Joachim C.
Boisseau, William
Leenaerts, Dorien
Di Meglio, Lucas
Loyau, Stéphane
Lambeir, Anne‐Marie
Ducroux, Célina
Jandrot‐Perrus, Martine
Michel, Jean‐Baptiste
Mazighi, Mikael
Hendriks, Dirk
Desilles, Jean‐Philippe
Source :
Journal of Thrombosis and Haemostasis; December 2020, Vol. 18 Issue: 12 p3325-3335, 11p
Publication Year :
2020

Abstract

Carboxypeptidase U (CPU, CPB2, TAFIa) is a potent attenuator of fibrinolysis. The inhibition of CPU is thus an interesting strategy for improving thrombolysis.

Details

Language :
English
ISSN :
15387933 and 15387836
Volume :
18
Issue :
12
Database :
Supplemental Index
Journal :
Journal of Thrombosis and Haemostasis
Publication Type :
Periodical
Accession number :
ejs62069298
Full Text :
https://doi.org/10.1111/jth.15071