Platelet andendothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis

Sepsis is associated with activation of platelets and endothelial cells accompanied by enhanced P-selectin surface expression. Both platelet- and endothelial P-selectin have been associated with leukocyte recruitment and induction of inflammatory alterations. Klebsiella (K.) pneumoniaeis a common human sepsis pathogen, particularly in the context of pneumonia.