Acute myeloid leukaemia following direct acting antiviral drugs in HCV-infected patients: A 10 years’ retrospective single-center study

•This is the first long term and comparative study analyzing the influence of anti-HCV DAA treatments on the onset of hematological malignancies.•Following DAA therapy, we describe a possible change in the pattern of hematological malignancies with a decrease of Non-Hodgkin Lymphoma and an increase of Acute Myeloid Leukemia.•We have observed the early onset of rare and severe form of biphenotypic Acute Leukaemia in 2 liver transplanted patients treated with DAA.•DAA related viral eradication may result in a decreased risk of HCV related B-cell lymphoma.