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Exendin-4 and GLP-1 decreases induced expression of ICAM-1, VCAM-1 and RAGE in human retinal pigment epithelial cells
- Source :
- Pharmacological Reports; July-August 2013, Vol. 65 Issue: 4 p884-890, 7p
- Publication Year :
- 2013
-
Abstract
- Advanced glycation end products (AGEs) take part in the development of diabetic retinopathy. Hyperglycemia triggers an inflammatory response in the retina. These mechanisms may lead to an enhanced expression of adhesion molecules (ICAM-1 and VCAM-1) in human retinal pigment epithelium (HRPE). Glucagon-like peptide 1 (GLP-1) functions as an incretin hormone with antidiabetogenic properties. GLP-1 also possesses vasoprotective properties.
Details
- Language :
- English
- ISSN :
- 17341140
- Volume :
- 65
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Pharmacological Reports
- Publication Type :
- Periodical
- Accession number :
- ejs61864800
- Full Text :
- https://doi.org/10.1016/S1734-1140(13)71069-7