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MAO-B Inhibitor, KDS2010, Alleviates Spinal Nerve Ligation-induced Neuropathic Pain in Rats Through Competitively Blocking the BDNF/TrkB/NR2B Signaling
- Source :
- Journal of Pain; December 2022, Vol. 23 Issue: 12 p2092-2109, 18p
- Publication Year :
- 2022
-
Abstract
- •KDS2010 alleviates spinal nerve ligation-induced neuropathic pain.•KDS2010 targets BDNF/TrkB/NR2B signaling in spinal dorsal horn neurons.•KDS2010 suppresses SNL-induced gliosis and inflammatory response in the spinal cord.
Details
- Language :
- English
- ISSN :
- 15265900 and 15288447
- Volume :
- 23
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Journal of Pain
- Publication Type :
- Periodical
- Accession number :
- ejs61828680
- Full Text :
- https://doi.org/10.1016/j.jpain.2022.07.010