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Prognosis of ALK-rearranged non-small-cell lung cancer patients carrying TP53mutations

Authors :
Canale, Matteo
Petracci, Elisabetta
Cravero, Paola
Mariotti, Marita
Minuti, Gabriele
Metro, Giulio
Ludovini, Vienna
Baglivo, Sara
Puccetti, Maurizio
Dubini, Alessandra
Martinelli, Giovanni
Delmonte, Angelo
Crinò, Lucio
Ulivi, Paola
Source :
Translational Oncology; September 2022, Vol. 23 Issue: 1
Publication Year :
2022

Abstract

•Non-small-cell lung cancer is the primary cause of cancer-related death. TP53mutations affect patients prognosis, also in oncogene-addicted subgroup. We investigated the role of TP53mutations in predicting response to therapy and prognosis in ALK-rearranged NSCLC patients, finding that specific TP53mutations are able to influence patients prognosis.

Details

Language :
English
ISSN :
19447124 and 19365233
Volume :
23
Issue :
1
Database :
Supplemental Index
Journal :
Translational Oncology
Publication Type :
Periodical
Accession number :
ejs61825591
Full Text :
https://doi.org/10.1016/j.tranon.2022.101471