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Aging alters the cell cycle control and mitogenic signaling responses of human hematopoietic stem cells
- Source :
- Blood; April 2023, Vol. 141 Issue: 16 p1990-2002, 13p
- Publication Year :
- 2023
-
Abstract
- •Aging HSCs display a progressive and growth-factor sensitive elongation of G1.•Increased growth factor concentrations are required to stimulate mitogenesis in aging HSCs associated with reduced AKT activation.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 141
- Issue :
- 16
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs61810877
- Full Text :
- https://doi.org/10.1182/blood.2022017174