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Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma

Authors :
Du, Ting
Song, Yan
Ray, Arghya
Wan, Xueping
Yao, Yao
Samur, Mehmet K.
Shen, Chen
Penailillo, Johany
Sewastianik, Tomasz
Tai, Yu-Tzu
Fulciniti, Mariateresa
Munshi, Nikhil C.
Wu, Hao
Carrasco, Ruben D.
Chauhan, Dharminder
Anderson, Kenneth C.
Source :
Blood; May 2023, Vol. 141 Issue: 21 p2599-2614, 16p
Publication Year :
2023

Abstract

•Rpn10 plays a pivotal role in MM.•A novel Rpn10 inhibitor, SB, was identified via AlphaScreen.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
141
Issue :
21
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs61671853
Full Text :
https://doi.org/10.1182/blood.2022017897