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Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury
- Source :
- Journal of the American Society of Nephrology; March 2022, Vol. 33 Issue: 3 p613-627, 15p
- Publication Year :
- 2022
-
Abstract
- Mechanisms underlying long-term effects after AKI remain unclear. Because vessel instability is an early response to endothelial injury, the authors studied markers of blood vessel homeostasis (the plasma angiopoietins angiopoietin-1 and angiopoietin-2) in a multicenter prospective cohort that included 1503 adults, half of whom had AKI. Three months after hospitalization, the highest quartile of plasma angiopoietin-1:angiopoietin-2 ratio compared with the lowest quartile associated with 72% less risk of CKD progression, 94% less risk of heart failure, and 82% less risk of death among those with AKI; those without AKI exhibited similar but less pronounced reductions in risk of heart failure and mortality. Angiopoietins may serve as a common pathway to explain the progression of kidney and heart disease after AKI and may point to potential future interventions.
Details
- Language :
- English
- ISSN :
- 10466673 and 15333450
- Volume :
- 33
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of the American Society of Nephrology
- Publication Type :
- Periodical
- Accession number :
- ejs61660153
- Full Text :
- https://doi.org/10.1681/ASN.2021060757