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Rare germline complement factor Hvariants in patients with paroxysmal nocturnal hemoglobinuria

Authors :
Prata, Pedro Henrique
Galimard, Jacques-Emmanuel
Sicre de Fontbrune, Flore
Duval, Anna
Vieira Martins, Paula
Roncelin, Stephane
Debureaux, Pierre-Édouard
Lepretre, Anne-Claire
Larcher, Lise
Birsen, Rudy
Benhamou, Ygal
Soulier, Jean
Socié, Gérard
Fremeaux-Bacchi, Véronique
Peffault de Latour, Régis
Source :
Blood; April 2023, Vol. 141 Issue: 15 p1812-1816, 5p
Publication Year :
2023

Abstract

•Rare germline CFHvariants are over-represented among patients with PNH.•Patients with PNH with rare germline CFHvariants were more likely to be transfusion-dependent under eculizumab.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
141
Issue :
15
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs61658225
Full Text :
https://doi.org/10.1182/blood.2022017019