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Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study
Authors :
Liu, Zhigang Le, Kaixing Zhou, Xin Alexander, James L Lin, Simeng Bewshea, Claire Chanchlani, Neil Nice, Rachel McDonald, Timothy J Lamb, Christopher A Sebastian, Shaji Kok, Klaartje Lees, Charlie W Hart, Ailsa L Pollok, Richard C Boyton, Rosemary J Altmann, Daniel M Pollock, Katrina M Goodhand, James R Kennedy, Nicholas A Ahmad, Tariq Powell, Nick Islam, Madiha Croft, Nick Cipriano, Bessie Francia, Caroline Khalid, Nosheen Kingston, Ashley Lee, Irish Lehmann, Anouk Naik, Kinnari Samuels, Kevin Plaatjies, Nicolene Khatun, Hafiza Bokth, Farjana Pabriaga, Elise Saich, Rebecca Cousins, Hayley Fraser, Wendy Thomas, Rachel Brown, Matthew White, Benjamin Kirkineziadis, Nikolaos Tilley, Bernadette Porter, Pennie Bryant, Rachel Robaczewska, Natalia Muhammed, Rafeeq Bi, Rehana Cotter, Catherine Grove, Jayne Hong, Kate Howman, Ruth Mitchell, Monica Clayton, Sophie Rogers, Louise Sultan, Sugrah Rooney, Melanie Cottrill, Charlotte Singh, Salil Dawe, Chris Hull, Robert Silva, Natalie Chadwick, Julie Robertson, Laura Manning, Jonathan Finlayson, Lauren Roebuck, Allison Dawson, Joy Sonwalkar, Sunil Chambers, Naomi Robinson, Matthew Haigh, Andrew Matapure, Lear Raine, Tim George, Varun Kapizioni, Christina Strongili, Konstantina Thompson, Tina Ahmed, Mohamed Kontos, Christos Dawson, Claire Bourges, Christophe Barbutti, Isabella Gozzard, Megan E Hendy, Philip Bull, Rhian Costa, Patricia Davey, Lisa Hannington, Hayley Nundlall, Kribashnie Martins, Catarina Avanzi, Laura Carungcong, Jaime Barr, Sabrina Appleby, Richard Johnson, Emma Shakweh, Eathar Phillis, Kath Gascoyne, Rachel Crowder, Amanda Whileman, Amanda London, Ian Grounds, Jenny Martin, Emmeline Pajak, Susie Price, Jude Cawley, Kathryn Powell, Sandra Kearsley, Nichola Dhar, Anjan Brown, Ellen Cowton, Amanda Stamp, Kimberley Warner, Ben Stuart, Carmel Lacey, Louise de Silva, Shanika Allcock, Clare Harvey, Philip Jones, Lesley Cooke, Elise Slater, Jayne King, Dominic Brooks, Johanne Baker, Pearl Beadle, Hannah Cruz, Carina Potter, Debbie Collum, Joe Masters, Farzana Kumar, Aashish Coetzee, Samantha Peiu, Mihaela Icke, Becky Williams, Jill Raj, Meena Gaynor, Edward Chadokufa, Sibongile Huggett, Bonita Meghari, Hamza El-Khouly, Sara Kiparissi, Fevronia Girshab, Waffa Russell-Walker, Lynda Jackson, Christopher Sidler, Sara Claridge, Andrew Fowler, Emily McCafferty, Laura Haxton, Lesley Irving, Peter Christodoulides, Karolina Clifford, Angela Dawson, Patrick Honap, Sailish Lim, Samuel Luber, Raphael Mahiouz, Karina Meade, Susanna Raymode, Parizade Reynolds, Rebecca Stanton, Anna Tripoli, Sherill Hare, Naomi Odukwe, Sopuluchukwu Balachandran, Senthuran North, Emma North, Jessica Browne, Bria Cordle, Jessica Jameson, Ella Siaw, Yih Harn Manzano, Lane Segal, Jonathan Al-Bakir, Ibrahim Khakoo, Imran Portukhay, Sofiya Thoua, Nora Davidson, Katherine Miah, Jagrul Canclini, Lisa Hall, Alex Furreed, Hassina Mitchell-Inwang, Christine Hayes, Melony Myers, Sally Talbot, Alison Turnbull, Jack Whitehead, Emma Stamp, Katie Pattinson, Alison Mathew, Verghese Sherris, Leanne Wilcox, Julie Ramachandran, Sankaranarayanan Robertson, Hayley Harvey, Angela Hicks, Lucy Byrne, Tara-Marie Cabreros, Leilani Downing-Wood, Hannah Hunter, Sophie Saifuddin, Mohammad Aamir Prabhudev, Hemanth Balarajah, Sharmili Krucznski, Jan Driva, Kalliopi D'Mello, Andrea Shah, Parith Castro-Seoane, Rocio Ibraheim, Hajir Constable, Laura E Lo, Jonathan W Torkizadeh, Melissa Hermangild, Sherine K Sutherland, Helen Wilhelmsen, Elva Mackintosh, Katherine Verma, Ajay M Sebastian, Juliemol Peerally, Mohammad Farhad Raymode, Parizade Guerdette, Anne-marie Coburn, Susan Novem lam, Ching Yee Durrant, Donna Schaefer, Belinda Serna, Solange Shahzad, Muhammad Kent, Alexandra Choong, Lee Meng Pantaloni, Benedetta Ravdas, Pantelis Vadamalayan, Babu Foley, Stephen Arnold, Becky Heeley, Cheryl Lovegrove, Wayne Sowton, Donna Allsop, Lynne Gregory, Heidi Gill, Mandy Holmes, Megan Balan, Valeria Smith, Susan Turner, Sarah Smith, Philip J Steel, Alan Bretland, Giovanna King, Sarah Lofthouse, Martina Rigby, Lindsey Subramanian, Sreedhar Tyrer, David Martin, Kate Probert, Christopher Kamperidis, Nikolaos Adedoyin, Temi Baden, Manisha Brown, Jeannette Chacko, Feba Young, Lisa Cicchetti, Michela Saifuddin, Mohammad Yesupatham, Priya Gowda, Rohit Williams, Maureen Kemp, Karen Akhand, Rima Gray, Glaxy John, Anu John, Maya Mohammed, Tasnim Sathe, Diamond Jones, Natasha Soren, Jennifer Sprakes, Michael Burton, Julie Kane, Patricia Lupton, Stephanie Bartholomew, Jacqueline Denis, Elizabeth Daniels, Alison MacFaul, George Scaletta, Diane Siamia, Loria Williams, Felicity Green, Chloe Ver, Zeljka Lamb, Chris Doona, Mary Hogg, Ashleigh Jeffrey, Lesley King, Andrew Speight, R Alexander Doyle, Jennifer Owen, Ruth Haworth, Jenny Patterson, Linda Varnaulasingam, Vithusa Mowat, Craig Rice, Debbie MacFarlane, Susan MacLeod, Anne Mohammed, Samera Murray, Shona Elliott, Anne Anne Morris, Mary Coke, Louise Hindle, Grace Kolokouri, Eirini Wright, Catherine Lee, Claire Ward, Nicola Dann, Adele Lockett, Melanie Cranfield, Charlotte Jennings, Louise Srivastava, Ankur Ward, Lana Jeynes, Nouf Ranga, Poonam Rajasekhar, Praveen Gallagher, Lisa Ward, Jill Basnett, Rae Murphy, Judy Parking, Lauren Lawson, Emma Short, Stacey Devadason, David Moran, Gordon Khan, Neelam Tarr, Lauren Olivia, Charmaine Warbarton, Samantha Kelly, Sian Limdi, Jimmy Goulden, Kay Javed, Asad McKenzie, Lauren Melville, Julie Liu, Eleanor Sabine, Joseph Jacob, Patricia McSorland, Denise Schofield, Nick Cornwall, Lisa Quirke, James Crook, Emma Turner, Anne Bhandari, Pradeep Baker-Moffatt, Michelle Dash, Joanne Le Poidevin, Alison Downe, Hayley Bombeo, Lucille Blackman, Helen Smith, Rebecca Wiles, Alan Bloxham, Hannah Dias, Jose Nadar, Evelyn Curgenven, Hollie Gilham, Ellie Macdonald, Jonathan Finan, Shona McMeeken, Faye Mahmood, Misbah Shields, Stephanie Seenan, John Paul DeSilva, Des Malkakorpi, Susanna Carson, Rachel Lawrence, Holly Boateng, Ofori Kpodo, Felix Whiteoak, Simon Edger-Earley, Kelli Vamplew, Luke Samways, Joanna Roffe, Sue Ingram, Sarah James, Joel Botfield, Sharon Hammonds, Fiona James, Clare Berry, Zoe Aspinall, Gemma Hawkins, Sarah Parkinson, Marian Gardner-Thorpe, Helen Marriott, Suzie Redstone, Clare Windak, Halina Adam, Ana-Marie Mabb, Hannah Stevenson, Emma Record, Jessica Murray, Charles Diaba, Cynthia Joseph, Fexy Pakou, Glykeria Gleeson, Yvonne Nunag, Annalyn Berrill, James Stroud, Natalie Pothecary, Carla Roche, Lisa Turner, Keri Deering, Lisa Israel, Lynda Baker, Evelyn Nash, Maxine Fagbemi, Andrew Jennings, Felicia Mayor, Imelda Wilson, Jill Wheeler, Alice Phillips, Nicola Gordon, John Levell, Emma Zagalo, Silvia Hoad, Ina Anil, Bindu Russell, Richard Henderson, Paul Millar, Margaret Alexakis, Christopher Michalak, Natalia Marriott, Cheryl Stone, Sarah Pristopan, Veronika Saunders, John Burton, Helen Cambridge, Vanessa Clark, Tonia Ekblad, Charlotte Hierons, Sarah Katebe, Joyce Saunsbury, Emma Perry, Rachel Brookes, Matthew Davies, Kathryn Green, Marie Plumbe, Ann Ormerod, Clare Christensen, Helen Howlett, Hannah Keen, Anne Ogor, Jonathan Greenhaigh, Marie Knowles, Karen Yin, Shanzi Poulaka, Maria Anthony, Alpha Newitt, Emily Trim, Fiona Casey, Ruth Seymour, Katherine Reed, Catherine Joy, Lijo Fogden, Edward Russell, Kalisha Hussain, Samia Phillips, Anne Abdulla, Muaad Butterworth, Jeff Adams, Colene Carnahan, Mandy Buckingham, Elizabeth Childs, Danielle Magness, Alison Stickley, Jo Motherwell, Nichola Tonks, Louise Gibson, Hannah Wistance, Kate Thomas, Caradog Brinkworth, Elaine Connor, Lynda Cook, Amanda Rees, Tabitha Harford, Rachel Farley, Sean Jones, Marie Wesley, Emma Moss, Alison Lucas, Jacob Lorimer, Claire Oleary, Maria Dixon, Maxine Goodchild, Fiona Twenlow, Rebecca Pawley, Corinne Ramadas, Arvind Tregonning, Julie Okeke, Olaku Jackson, Wendy Koumoutsos, Ioannis George, Viji Kunhunny, Swapna Laverick, Sophie Anderson, Isla Smith, Sophie Joyce, Joan Janarthan, Sarala Patel, Kamal Ali, Mariam Mhandu, Hilda Rana, Aleem Spears, Katherine Teixeira, Joana Mencias, Mark Seaward, Abigail Sousa, Jessica Said, Nooria Soomaroo, Mark Raspa, Valentina Tacouri, Asha Reps, Nicholas Martin, Rebecca Samakomva, Tinashe Selinger, Christian Carbonell, Jenelyn Onovira, Felicia Quartey, Doris L'Anson, Alice Ashworth, Andrew Bailey, Jessica Dunn, Angie Bespaloi, Gjuzel Rasalan, Harold Mahmood, Zahid Campbell, Racheal Marsh, Liane Coughlan, Tricia Jafar, Wisam Marrs, Janet McPheat, Christopher Rahman, Monira Davies, Sarah Habibi, Ruth Jessup-Dunton, Ellen Joefield, Teishel Layug, Reina Patel, Vinod Vere, Joanne Turner, Victoria Kilroy, Susan Coulding, Martina Clark, Martyn McCormick, Jacqueline Nisar, Attiya Walker, Gareth Atkins, Stacey Growdon, Jasmine George, Becky McNeill, Charlotte Reed, Bryony Foulds, Angela Marshall, Catherine Allison, Michele Dillon, Briony Cooney, Rachel Bennett, Lillie Bowlas, Louise Shariff, Sharafaath Fraser, Aileen Punnette, Dwayne Lambert, Rebecca Bishop-Hurman, Charlotte Undrell, Elizabeth Belfield, Katherine Din, Said Addleton, Catherine Appleby, Marie Brown, Johanna Holding, Kathleen Fraser, Catherine Birkenshaw, Janice Williams, Jodie Maulion, Kamille Lane, Meg Kravale, Arita Smith, Claud Hooper, Patricia deCaestecker, John Watchorn, Olivia Clarke, Ellie Hayward, Chris Inniss, Susan Pritchard, Lucy Rudge, Karen Carney, Amanda Griffee, Sarah Andreyev, Jervoise Babu, Sathish Hayhurst, Caroline Lockwood, Carol Osborne, Lynn Roper, Amanda Warner, Karen Hindle, Julia Lawrence, Tara Netherton, Kimberley Watt, Caroline Szymiczek, Kinga Mehta, Shameer Bell, James Blad, William Whitley, Lisa Jastrub, Roman Durai, Dhamaraj Baker, Mark John Sivamurugan, Elizabeth Evans, Mim Cummings, Fraser Harris, Clare Jones, Amy Krauze, Liga Rahmany, Sohail Earl, Michelle Vowles, Jenny Torokwa, Audrey Petrova, Mirela Procter, Andrew Stanley, Jo Silvamoniz, Claudia Bettey, Marion Wahid, Amar Morrison, Zoe Thomas-Turner, Rhian Yendle, Louise Muller, Jennifer Mitchell, Marcus Kirkwood, John Barnes, Anna Chaudhary, Rakesh Claridge, Melanie Ellis, Chiara Kemp, Cheryl Tobi, Ogwa Milton, Jentus Johnston, Emma Oblak, Metod Winpenny, Carmen Svensson, Marie-Louise Godden, Jo Ashhar, Marium Alexander, Debbie Covil, Kate Derikx, Lauranne Siakavellas, Sryros Baxter, Helen Robertson, Scott Smith, Linda Poulose, Beena Colemam, Anne Balint, Margareta Rhys-Jones, Gareth Watters, Helen Begg, Susan Grosalcalde, Beatriz Coyle, Judy Johns, Kerrie Hughes, Rachel Phipps, Janet Taylor, Abigail MacPhee, Catherine Brooks, Suzanne John, Jolene Edwards, Michelle Smith, Katie Howard, Linda Wood, Dianne Muddu, Ajay Barman, Laura Mallinson, Janine Neale, Tania Ionita, Diana Elliot, Kerry Turnball, Alison Thomas, Iola Thomas, Alice Andrews, Kelly Sutton, Jonathon Mulvaney Jones, Caroline Roberts, Julia Bishop, Jeannie
Source :
The Lancet Gastroenterology & Hepatology; February 2023, Vol. 8 Issue: 2 p145-156, 12p
Publication Year :
2023
Abstract
Anti-TNF drugs, such as infliximab, are associated with attenuated antibody responses after SARS-CoV-2 vaccination. We aimed to determine how the anti-TNF drug infliximab and the anti-integrin drug vedolizumab affect vaccine-induced neutralising antibodies against highly transmissible omicron (B.1.1.529) BA.1, and BA.4 and BA.5 (hereafter BA.4/5) SARS-CoV-2 variants, which possess the ability to evade host immunity and, together with emerging sublineages, are now the dominating variants causing current waves of infection.
Details
Language :
English
ISSN :
24681253
Volume :
8
Issue :
2
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs61609328
Full Text :
https://doi.org/10.1016/S2468-1253(22)00389-2