Back to Search Start Over

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

Authors :
Xu, Wenjuan
Wang, Longde
Niu, Yuanyuan
Mao, Lanfang
Du, Xiaojuan
Zhang, Ping
Li, Zhengju
Li, Hongfang
Li, Ning
Source :
European Journal of Gastroenterology and Hepatology; February 2023, Vol. 35 Issue: 2 p133-152, 20p
Publication Year :
2023

Abstract

Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions. However, the antifibrosis drugs with ideal clinical efficacy are still insufficient. The edible plant-derived natural compounds have been reported to exert effective antifibrotic effects with few side-effects, representing a kind of promising source for the treatment of liver fibrosis. In this article, we reviewed the current progress of the natural compounds derived from dietary plants in the treatment of liver fibrosis, including phenolic compounds (capsaicin, chlorogenic acid, curcumin, ellagic acid, epigallocatechin-3-gallate, resveratrol, sinapic acid, syringic acid, vanillic acid and vitamin E), flavonoid compounds (genistein, hesperidin, hesperetin, naringenin, naringin and quercetin), sulfur-containing compounds (S-allylcysteine, ergothioneine, lipoic acid and sulforaphane) and other compounds (betaine, caffeine, cucurbitacin B, lycopene, α-mangostin, γ-mangostin, ursolic acid, vitamin C and yangonin). The pharmacological effects and related mechanisms of these compounds in in-vivo and in-vitro models of liver fibrosis are focused.

Details

Language :
English
ISSN :
0954691X and 14735687
Volume :
35
Issue :
2
Database :
Supplemental Index
Journal :
European Journal of Gastroenterology and Hepatology
Publication Type :
Periodical
Accession number :
ejs61537225
Full Text :
https://doi.org/10.1097/MEG.0000000000002483