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Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms
- Source :
- Blood; February 2023, Vol. 141 Issue: 8 p917-929, 13p
- Publication Year :
- 2023
-
Abstract
- •Mutant CALR proteins are secreted in complex with sTFR1 to the plasma of MPN patients and activate the TpoR in a rogue cytokine fashion.•TpoR-expressing cells with a CALRmutation are uniquely sensitive to the levels of circulating mutant CALR proteins seen in patients.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 141
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs61524641
- Full Text :
- https://doi.org/10.1182/blood.2022016846