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Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials

Authors :
Dawed, Adem Y
Mari, Andrea
Brown, Andrew
McDonald, Timothy J
Li, Lin
Wang, Shuaicheng
Hong, Mun-Gwan
Sharma, Sapna
Robertson, Neil R
Mahajan, Anubha
Wang, Xuan
Walker, Mark
Gough, Stephen
Hart, Leen M ‘t
Zhou, Kaixin
Forgie, Ian
Ruetten, Hartmut
Pavo, Imre
Bhatnagar, Pallav
Jones, Angus G
Pearson, Ewan R
't Hart, L.M.
Abdalla, M.
Adam, J.
Adamski, J.
Adragni, K.
Allin, K.H.
Arumugam, M.
Atabaki Pasdar, N.
Baltauss, T.
Banasik, K.B.
Baum, P.
Bell, J.D.
Bergstrom, M.
Beulens, J.W.
Bianzano, S.
Bizzotto, R.
Bonneford, A.
Brorsson, C.A.B.
Brown, A.A.
Brunak, S.B.
Cabrelli, L.
Caiazzo, R.
Canouil, M.
Dale, M.
Davtian, D.
Dawed, A.Y.
De Masi, F.M.
de Preville, N.
Dekkers, K.F.
Dermitzakis, E.T.
Deshmukh, H.A.
Dings, C.
Donnelly, L.
Dutta, A.
Ehrhardt, B.
Elders, P.J.M.
Engel Thomas, C.E.T.
Engelbrechtsen, L.
Eriksen, R.G.
Eriksen, R.E.
Fan, Y.
Fernandez, J.
Ferrer, J.
Fitipaldi, H.
Forgie, I.M.
Forman, A.
Franks, P.W.
Frau, F.
Fritsche, A.
Froguel, P.
Frost, G.
Gassenhuber, J.
Giordano, G.N.
Giorgino, T.
Gough, S.
Graefe-Mody, U.
Grallert, H.
Grempler, R.
Groeneveld, L.
Groop, L.
Gudmundsdóttir, V.G.
Gupta, R.G.
Haid, M.
Hansen, T.
Hansen, T.H.
Hattersley, A.T.
Haussler, R.S.
Heggie, A.J.
Hennige, A.M.
Hill, A.V.
Holl, R.W.
Hong, M.-G.
Hudson, M.
Jablonka, B.
Jennison, C.
Jiao, J.
Johansen, J.J.
Jones, A.G.
Jonsson, A.
Karaderi, T.K.
Kaye, J.
Klintenberg, M.
Koivula, R.W.
Kokkola, T.
Koopman, A.D.M.
Kurbasic, A
Kuulasmaa, T.
Laakso, M.
Lehr, T.
Loftus, H.
Lundbye Allesøe, R.L.A
Mahajan, A.
Mari, A.
Mazzoni, G.M.
McCarthy, M.I.
McDonald, T.J.
McEvoy, D.
McRobert, N.
McVittie, I.
Mourby, M.
Musholt, P.
Mutie, P
Nice, R.
Nicolay, C.
Nielsen, A.M.N.
Nilsson, B.N.
Palmer, C.N.
Pattou, F.
Pavo, I.
Pearson, E.R.
Pedersen, O.
Pedersen, H.K.P.
Perry, M.H.
Pomares-Millan, H.
Ramisch, A.
Rasmussen, S.R.
Raverdi, V.
Ridderstrale, M.
Robertson, N.
Roderick, R.C.
Rodriquez, M.
Ruetten, H.
Rutters, F.
Sackett, W.
Scherer, N.
Schwenk, J.M.
Shah, N.
Sharma, S.
Sihinevich, I.
Sondertoft, N.B.
Staerfeldt, H.
Steckel-Hamann, B.
Teare, H.
Thomas, M.K.
Thomas, E.L.
Thomsen, H.S.
Thorand, B.
Thorne, C.E.
Tillner, J.
Troen Lundgaard, A.T.L.
Troll, M.
Tsirigos, K.D.T.
Tura, A.
Uhlen, M.
van Leeuwen, N.
van Oort, S.
Verkindt, H.
Vestergaard, H.
Viñuela, A.
Vogt, J.K
Wad Sackett, P.W.S
Wake, D.
Walker, M.
Wesolowska-Andersen, A.
Whitcher, B.
White, M.W.
Wu, H.
Source :
The Lancet Diabetes & Endocrinology; January 2023, Vol. 11 Issue: 1 p33-41, 9p
Publication Year :
2023

Abstract

In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacogenomic studies of this inter-individual variation can provide both biological insight into drug action and provide biomarkers to inform clinical decision making. We therefore aimed to identify genetic variants associated with glycaemic response to GLP-1 receptor agonist treatment.

Details

Language :
English
ISSN :
22138587 and 22138595
Volume :
11
Issue :
1
Database :
Supplemental Index
Journal :
The Lancet Diabetes & Endocrinology
Publication Type :
Periodical
Accession number :
ejs61441660
Full Text :
https://doi.org/10.1016/S2213-8587(22)00340-0
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