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Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial
Authors :
Slobogean, Gerard P. Sprague, Sheila Wells, Jeffrey L. Bhandari, Mohit Harris, Anthony D. Mullins, C. Daniel Thabane, Lehana Wood, Amber Della Rocca, Gregory J. Hebden, Joan N. Jeray, Kyle J. Marchand, Lucas S. O'Hara, Lyndsay M. Zura, Robert D. Lee, Christopher Patterson, Joseph T. Gardner, Michael J. Blasman, Jenna Davies, Jonah Liang, Stephen Taljaard, Monica Devereaux, PJ Guyatt, Gordon Heels-Ansdell, Diane Marvel, Debra Palmer, Jana E. Friedrich, Jeff O'Hara, Nathan N. Grissom, Frances Gitajn, I. Leah Morshed, Saam O'Toole, Robert V. Petrisor, Bradley Mossuto, Franca Joshi, Manjari G. D'Alleyrand, Jean-Claude G. Fowler, Justin Rivera, Jessica C. Talbot, Max Pogorzelski, David Dodds, Shannon Li, Silvia Del Fabbro, Gina Szasz, Olivia Paige Bzovsky, Sofia McKay, Paula Minea, Alexandra Murphy, Kevin Howe, Andrea L. Demyanovich, Haley K. Hoskins, Wayne Medeiros, Michelle Polk, Genevieve Kettering, Eric Mahal, Nirmen Eglseder, Andrew Johnson, Aaron Langhammer, Christopher Lebrun, Christopher Nascone, Jason Pensy, Raymond Pollak, Andrew Sciadini, Marcus Degani, Yasmin Phipps, Heather Hempen, Eric Johal, Herman Ristevski, Bill Williams, Dale Denkers, Matthew Rajaratnam, Krishan Al-Asiri, Jamal Gallant, Jodi L. Pusztai, Kaitlyn MacRae, Sarah Renaud, Sara Adams, John D. Beckish, Michael L. Bray, Christopher C. Brown, Timothy R. Cross, Andrew W. Dew, Timothy Faucher, Gregory K. Gurich Jr, Richard W. Lazarus, David E. Millon, S. John Moody, M. Christian Palmer, M. Jason Porter, Scott E. Schaller, Thomas M. Sridhar, Michael S. Sanders, John L. Rudisill Jr, L. Edwin Garitty, Michael J. Poole, Andrew S. Sims, Michael L. Walker, Clark M. Carlisle, Robert Hofer, Erin A. Huggins, Brandon Hunter, Michael Marshall, William Ray, Shea B. Smith, Cory Altman, Kyle M. Pichiotino, Erin R. Quirion, Julia C. Loeffler, Markus F. Cole, Austin A. Maltz, Ethan J. Parker, Wesley Ramsey, T. Bennett Burnikel, Alex Colello, Michael Stewart, Russell Wise, Jeremy Anderson, Matthew Eskew, Joshua Judkins, Benjamin Miller, James M. Tanner, Stephanie L. Snider, Rebecca G. Townsend, Christine E. Pham, Kayla H. Martin, Abigail Robertson, Emily Bray, Emily Sykes, J. Wilson Yoder, Krystina Conner, Kelsey Abbott, Harper Natoli, Roman M. McKinley, Todd O. Virkus, Walter W. Sorkin, Anthony T. Szatkowski, Jan P. Mullis, Brian H. Jang, Yohan Lopas, Luke A. Hill, Lauren C. Fentz, Courteney L. Diaz, Maricela M. Brown, Krista Garst, Katelyn M. Denari, Emma W. Osborn, Patrick Pierrie, Sarah N. Kessler, Bradley Herrera, Maria Miclau, Theodore Marmor, Meir T. Matityahu, Amir McClellan, R. Trigg Shearer, David Toogood, Paul Ding, Anthony Murali, Jothi El Naga, Ashraf Tangtiphaiboontana, Jennifer Belaye, Tigist Berhaneselase, Eleni Pokhvashchev, Dmitry Obremskey, William T. Jahangir, Amir Alex Sethi, Manish Boyce, Robert Stinner, Daniel J. Mitchell, Phillip P. Trochez, Karen Rodriguez, Elsa Pritchett, Charles Hogan, Natalie Fidel Moreno, A. Hagen, Jennifer E. Patrick, Matthew Vlasak, Richard Krupko, Thomas Talerico, Michael Horodyski, Marybeth Pazik, Marissa Lossada-Soto, Elizabeth Gary, Joshua L. Warner, Stephen J. Munz, John W. Choo, Andrew M. Achor, Timothy S. Routt, Milton L. “Chip” Kutzler, Michael Boutte, Sterling Warth, Ryan J. Prayson, Michael J. Venkatarayappa, Indresh Horne, Brandon Jerele, Jennifer Clark, Linda Boulton, Christina Lowe, Jason Ruth, John T. Askam, Brad Seach, Andrea Cruz, Alejandro Featherston, Breanna Carlson, Robin Romero, Iliana Zarif, Isaac Dehghan, Niloofar McKee, Michael Jones, Clifford B. Sietsema, Debra L. Williams, Alyse Dykes, Tayler Guerra-Farfan, Ernesto Tomas-Hernandez, Jordi Teixidor-Serra, Jordi Molero-Garcia, Vicente Selga-Marsa, Jordi Porcel-Vazquez, Juan Antonio Andres-Peiro, Jose Vicente Esteban-Feliu, Ignacio Vidal-Tarrason, Nuria Serracanta, Jordi Nuñez-Camarena, Jorge del Mar Villar-Casares, Maria Mestre-Torres, Jaume Lalueza-Broto, Pilar Moreira-Borim, Felipe Garcia-Sanchez, Yaiza Marcano-Fernández, Francesc Martínez-Carreres, Laia Martí-Garín, David Serrano-Sanz, Jorge Sánchez-Fernández, Joel Sanz-Molero, Matsuyama Carballo, Alejandro Pelfort, Xavier Acerboni-Flores, Francesc Alavedra-Massana, Anna Anglada-Torres, Neus Berenguer, Alexandre Cámara-Cabrera, Jaume Caparros-García, Ariadna Fillat-Gomà, Ferran Fuentes-López, Ruben Garcia-Rodriguez, Ramona Gimeno-Calavia, Nuria Martínez-Álvarez, Marta Martínez-Grau, Patricia Pellejero-García, Raúl Ràfols-Perramon, Ona Peñalver, Juan Manuel Salomó Domènech, Mònica Soler-Cano, Albert Velasco-Barrera, Aldo Yela-Verdú, Christian Bueno-Ruiz, Mercedes Sánchez-Palomino, Estrella Andriola, Vito Molina-Corbacho, Matilde Maldonado-Sotoca, Yeray Gasset-Teixidor, Alfons Blasco-Moreu, Jorge Fernández-Poch, Núria Rodoreda-Puigdemasa, Josep Verdaguer-Figuerola, Arnau Cueva-Sevieri, Heber Enrique Garcia-Gimenez, Santiago Viskontas, Darius G. Apostle, Kelly L. Boyer, Dory S. Moola, Farhad O. Perey, Bertrand H. Stone, Trevor B. Lemke, H. Michael Spicer, Ella Payne, Kyrsten Hymes, Robert A. Schwartzbach, Cary C. Schulman, Jeff E. Malekzadeh, A. Stephen Holzman, Michael A. Gaski, Greg E. Wills, Jonathan Pilson, Holly Carroll, Eben A. Halvorson, Jason J. Babcock, Sharon Goodman, J. Brett Holden, Martha B. Williams, Wendy Hill, Taylor Brotherton, Ariel Romeo, Nicholas M. Vallier, Heather A. Vergon, Anna Higgins, Thomas F. Haller, Justin M. Rothberg, David L. Olsen, Zachary M. McGowan, Abby V. Hill, Sophia Dauk, Morgan K. Bergin, Patrick F. Russell, George V. Graves, Matthew L. Morellato, John McGee, Sheketha L. Bhanat, Eldrin L. Yener, Ugur Khanna, Rajinder Nehete, Priyanka Potter, David VanDemark III, Robert Seabold, Kyle Staudenmier, Nicholas Coe, Marcus Dwyer, Kevin Mullin, Devin S. Chockbengboun, Theresa A. DePalo Sr., Peter A. Phelps, Kevin Bosse, Michael Karunakar, Madhav Kempton, Laurence Sims, Stephen Hsu, Joseph Seymour, Rachel Churchill, Christine Mayfield, Ada Sweeney, Juliette Jaeblon, Todd Beer, Robert Bauer, Brent Meredith, Sean Talwar, Sneh Domes, Christopher M. Gage, Mark J. Reilly, Rachel M. Paniagua, Ariana Dupree, JaNell Weaver, Michael J. von Keudell, Arvind G. Sagona, Abigail E. Mehta, Samir Donegan, Derek Horan, Annamarie Dooley, Mary Heng, Marilyn Harris, Mitchel B. Lhowe, David W. Esposito, John G. Alnasser, Ahmad Shannon, Steven F. Scott, Alesha N. Clinch, Bobbi Weber, Becky Beltran, Michael J. Archdeacon, Michael T. Sagi, Henry Claude Wyrick, John D. Le, Theodore Toan Laughlin, Richard T. Thomson, Cameron G. Hasselfeld, Kimberly Lin, Carol A. Vrahas, Mark S. Moon, Charles N. Little, Milton T. Marecek, Geoffrey S. Dubuclet, Denice M. Scolaro, John A. Learned, James R. Lim, Philip K. Demas, Susan Amirhekmat, Arya Dela Cruz, Yan Marco
Source :
The Lancet; October 2022, Vol. 400 Issue: 10360 p1334-1344, 11p
Publication Year :
2022
Abstract
Chlorhexidine skin antisepsis is frequently recommended for most surgical procedures; however, it is unclear if these recommendations should apply to surgery involving traumatic contaminated wounds where povidone-iodine has previously been preferred. We aimed to compare the effect of aqueous 10% povidone-iodine versus aqueous 4% chlorhexidine gluconate on the risk of surgical site infection in patients who required surgery for an open fracture.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
400
Issue :
10360
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs61437829
Full Text :
https://doi.org/10.1016/S0140-6736(22)01652-X