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Hedychins E and F: Labdane-Type Norditerpenoids with Anti-Inflammatory Activity from the Rhizomes of Hedychium forrestii
- Source :
- Organic Letters; September 2022, Vol. 24 Issue: 38 p6936-6939, 4p
- Publication Year :
- 2022
-
Abstract
- Hedychin E (1), a novel labdane-type norditerpenoid, and hedychin F (2), a new labdane-type dinorditerpenoid, were isolated from the rhizomes of Hedychium forrestii. Their structures were determined through a combination of spectroscopic analysis and X-ray single-crystal diffractions. Hedychin E (1) is an unprecedented 6-norditerpenoid with a fused tetrahydrofuran-lactone motif, and a reasonable biosynthetic pathway for 1was proposed. Compound 2showed a significant anti-inflammatory effect against LPS-induced NO production in macrophage RAW264.7 cells with an IC50value of 21.0 μM.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 24
- Issue :
- 38
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs60857306
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c02710