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141 Cognitive processing speed predicts disease progression in SPMS: post hoc analysis from the EXPAND study
- Source :
- Journal of Neurology, Neurosurgery, & Psychiatry (JNNP); 2022, Vol. 93 Issue: 9 pe2-cq-e2-cq, 1p
- Publication Year :
- 2022
-
Abstract
- ObjectiveAssess the predictive value of cognitive processing speed (CPS), using the Symbol Digit Modali- ties Test (SDMT) score, on disability progression in secondary progressive multiple sclerosis (SPMS).Design/MethodsSPMS patients from the Phase 3 EXPAND study (core part [CP] and core+extension part [CP+EP]) were categorised into quartiles of baseline SDMT score (worst-WQ [Q1], intermediate [Q2-Q3], and best-BQ [Q4] quartile). The predictive value of baseline SDMT quartiles for time-to-wheelchair (T2W; i.e., Expanded Disability Status Scale [EDSS] score ≥7) sustained until end of follow-up, or 6-month confirmed disability progression (6mCDP) by EDSS, were assessed at the end of the CP (up to 37-months) and CP+EP (up to 5-years) by Cox regression (adjusted for treatment, age, gender, baseline EDSS, baseline SDMT quartile, and treatment-by-baseline SDMT quartile interaction).ResultsAnalyses included 1628/1651 patients (98.6%) randomised in EXPAND (baseline SDMT: WQ, n=435; intermediate, n=808; BQ, n=385). Risk of T2W (WQ vs BQ) was higher in the CP (HRWQ/BQ=1.31, 95% CI:0.72–2.38; p=0.37) and increased with long-term follow-up (HRWQ/BQ=1.81; 1.17–2.78; p=0.01). Baseline SDMT was not predictive of 6mCDP. The predictive value of on-study SDMT score change will be presented.ConclusionsThe results support the predictive value of CPS for long-term physical disability progression in SPMS. Funding: Novartis Pharma AG, Basel, Switzerland.
Details
- Language :
- English
- ISSN :
- 00223050 and 1468330X
- Volume :
- 93
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Journal of Neurology, Neurosurgery, & Psychiatry (JNNP)
- Publication Type :
- Periodical
- Accession number :
- ejs60602081
- Full Text :
- https://doi.org/10.1136/jnnp-2022-abn2.185