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A New Antitumoral Agent: 9-Hydroxyellipticine. Possibility of a Rational Design of Anticancerous Drugs in the Series of DNA Intercalating Drugs
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; December 1974, Vol. 71 Issue: 12 p5078-5082, 5p
- Publication Year :
- 1974
-
Abstract
- The designing of DNA intercalating drugs with high DNA affinity in the series of ellipticine has led to a new antitumoral agent, 9-hydroxyellipticine, which has a high DNA affinity, a high activity on L 1210 mice leukemia, and a lack of toxicity at therapeutic dose. The possible correlations among chemical structure, DNA reactivity, and pharmacological activity of DNA intercalating drugs are discussed.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 71
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60451155
- Full Text :
- https://doi.org/10.1073/pnas.71.12.5078