Back to Search
Start Over
Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; June 1981, Vol. 78 Issue: 6 p3521-3525, 5p
- Publication Year :
- 1981
-
Abstract
- We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat alpha a-fetoprotein mRNA. The resultant nucleotide sequence of alpha-fetoprotein was exhaustively compared to the nucleotide sequence of the mRNA encoding rat serum albumin. These two mRNAs have extensive homology (50%) throughout and the same intron locations. The amino acid sequence of rat alpha-fetoprotein has been deduced from the nucleotide sequence, and its comparison to rat serum albumin's amino acid sequence reveals a 34% homology. The regularly spaced positions of the cysteines found in serum albumin are conserved in rat alpha-fetoprotein, indicating that these two proteins may have a similar secondary folding structure. These homologies indicate that alpha-fetoprotein and serum albumin were derived by duplication of a common ancestral gene and constitute a gene family.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 78
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60449889
- Full Text :
- https://doi.org/10.1073/pnas.78.6.3521