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Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; October 1985, Vol. 82 Issue: 19 p6595-6599, 5p
- Publication Year :
- 1985
-
Abstract
- The cell-derived domain of Gardner-Rasheed feline sarcoma virus (GR-FeSV) consists of a gamma-actin- and a tyrosine-specific protein kinase-encoding sequence designated v-fgr. By utilizing a v-fgr probe, it was possible to detect related sequences present at low copy number in DNAs of a variety of mammalian species and to isolate a human fgr homologue. Comparative studies revealed that this human DNA clone represented all but 200 base pairs of v-fgr. Analysis of human genomic DNA demonstrated that the fgr protooncogene was distinct from the cellular homologues of other retrovirus onc genes. In addition, the fgr protooncogene was localized to the distal portion of the short arm of human chromosome 1 at p36.1-36.2 by in situ hybridization. Taken together, our findings establish that the fgr protooncogene is a unique member of the tyrosine kinase gene family.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 82
- Issue :
- 19
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60448363
- Full Text :
- https://doi.org/10.1073/pnas.82.19.6595