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Localization of c-ras oncogene family on human germ-line chromosomes.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; August 1983, Vol. 80 Issue: 15 p4794-4797, 4p
- Publication Year :
- 1983
-
Abstract
- The c-ras family is a set of c-onc genes that are highly conserved in vertebrates. The genes in this family are homologous to the transforming genes of Harvey and Kirsten murine sarcoma viruses (v-Ha-ras and v-Ki-ras, respectively). Using an in situ molecular hybridization method, we detected three sites on the human pachytene chromosomes that exhibited significant hybridization to v-Ki-ras and v-Ha-ras probes. These were chromomere positions that corresponded to bands 11p14.1, 12p12.1, and 12q24.2 of somatic chromosomes. The relationship between these chromosomal sites and previously defined members of the human c-ras gene family is discussed. These chromosomal sites are known to be involved in specific chromosome changes in a variety of tumors and in several congenital disorders that predispose to neoplastic disease.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 80
- Issue :
- 15
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60443184
- Full Text :
- https://doi.org/10.1073/pnas.80.15.4794