Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.

Authors :: Huggins, C B
Grand, L
Ueda, N
Source :: Proceedings of the National Academy of Sciences of the United States of America; September 1982, Vol. 79 Issue: 17 p5411-5414, 4p
Publication Year :: 1982
Abstract: The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.

Language :: English
ISSN :: 00278424 and 10916490
Volume :: 79
Issue :: 17
Database :: Supplemental Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Periodical
Accession number :: ejs60432868
Full Text :: https://doi.org/10.1073/pnas.79.17.5411

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