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Nucleotide sequences of the 3'-terminal untranslated region of messenger RNA for human beta globin chain.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; September 1975, Vol. 72 Issue: 9 p3614-3618, 5p
- Publication Year :
- 1975
-
Abstract
- In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a frameshift mutation allowing the "readthrough" of the normal termination codon and translation of usually untranslated portions of the messenger RNA for the beta-globin chain. The oligonucleotides which match the amino-acid sequence of hemoglobin Cranston provide a sequence of 36 nucleotides which follows the normal beta-chain termination codon UAA.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 72
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60427995
- Full Text :
- https://doi.org/10.1073/pnas.72.9.3614