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Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; August 1976, Vol. 73 Issue: 8 p2872-2876, 5p
- Publication Year :
- 1976
-
Abstract
- A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological investigations performed on immunized mice reveal a neuromuscular block similar to that found in myasthenia gravis. Not a single mouse with objective signs of muscular weakness was lacking anti-mouse acetylcholine receptor antibodies but no correlation was found between their level and the severity of the disease.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 73
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60427595
- Full Text :
- https://doi.org/10.1073/pnas.73.8.2872