Back to Search
Start Over
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
- Source :
- GeroScience; December 2022, Vol. 44 Issue: 6 p2771-2783, 13p
- Publication Year :
- 2022
-
Abstract
- Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n= 31, 11 female, 20 male, mean age: 28.4 + / − 4.2 years) and aged volunteers (n= 32, 18 female, 14 male, mean age: 67.9 + / − 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults.
Details
- Language :
- English
- ISSN :
- 25092715 and 25092723
- Volume :
- 44
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- GeroScience
- Publication Type :
- Periodical
- Accession number :
- ejs60402948
- Full Text :
- https://doi.org/10.1007/s11357-022-00623-2