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Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial

Authors :
Strauss, Kevin A.
Farrar, Michelle A.
Muntoni, Francesco
Saito, Kayoko
Mendell, Jerry R.
Servais, Laurent
McMillan, Hugh J.
Finkel, Richard S.
Swoboda, Kathryn J.
Kwon, Jennifer M.
Zaidman, Craig M.
Chiriboga, Claudia A.
Iannaccone, Susan T.
Krueger, Jena M.
Parsons, Julie A.
Shieh, Perry B.
Kavanagh, Sarah
Tauscher-Wisniewski, Sitra
McGill, Bryan E.
Macek, Thomas A.
Source :
Nature Medicine; July 2022, Vol. 28 Issue: 7 p1381-1389, 9p
Publication Year :
2022

Abstract

For presymptomatic infants at risk for SMA type 1, onasemnogene abeparvovec improves motor outcomes, ventilator-free survival, and nutritional/respiratory independence compared with untreated or treated symptomatic patients

Details

Language :
English
ISSN :
10788956 and 1546170X
Volume :
28
Issue :
7
Database :
Supplemental Index
Journal :
Nature Medicine
Publication Type :
Periodical
Accession number :
ejs60219415
Full Text :
https://doi.org/10.1038/s41591-022-01866-4