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Constituents of Croton megalocarpuswith Potential Anti-HIV Activity
- Source :
- Journal of Natural Products; July 2022, Vol. 85 Issue: 7 p1861-1866, 6p
- Publication Year :
- 2022
-
Abstract
- Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the previously undescribed 11β-acetoxycrotocascarin L (2) and a known compound, crotocascarin K (3), were isolated from the bark of Croton megalocarpus, a Kenyan oil-producing seed crop. Compounds 1and 3inhibited HIV-1 replication with IC50values of 28 and 5.5 nM, respectively. Furthermore, both compounds lacked cytotoxicity toward MT-4 cells and FM-55-M1 cells at concentrations of up to 50 μM. Compounds 1and 3were both found to inhibit HIV-1 protease.
Details
- Language :
- English
- ISSN :
- 01633864 and 15206025
- Volume :
- 85
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Journal of Natural Products
- Publication Type :
- Periodical
- Accession number :
- ejs60181567
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.1c01013