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Myotonic Response Induced by Inhibitors of Cholesterol Biosynthesis
- Source :
- Science; July 1966, Vol. 153 Issue: 3733 p312-313, 2p
- Publication Year :
- 1966
-
Abstract
- Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholesterol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Volume :
- 153
- Issue :
- 3733
- Database :
- Supplemental Index
- Journal :
- Science
- Publication Type :
- Periodical
- Accession number :
- ejs60077311
- Full Text :
- https://doi.org/10.1126/science.153.3733.312