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Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery

Authors :
Barbosa, Ricardo Antonio G.
Jorge Santos, Silvia Regina C.
White, Paul F.
Pereira, Valéria A.
Silva Filho, Carlos R.
Malbouisson, Luiz M.S.
Carmona, Maria José C.
Source :
Clinics; March 2009, Vol. 64 Issue: 3 p215-221, 7p
Publication Year :
2009

Abstract

Cardiopulmonary bypass is known to alter propofol pharmacokinetics in patients undergoing cardiac surgery. However, few studies have evaluated the impact of these alterations on postoperative pharmacodynamics. This study was designed to test the hypothesis that changes in propofol pharmacokinetics increase hypnotic effects after cardiopulmonary bypass.

Details

Language :
English
ISSN :
18075932 and 19805322
Volume :
64
Issue :
3
Database :
Supplemental Index
Journal :
Clinics
Publication Type :
Periodical
Accession number :
ejs59919440
Full Text :
https://doi.org/10.1590/S1807-59322009000300012