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S-Nitroso-N-Acetylcysteine Ameliorates Ischemia-Reperfusion Injury In The Steatotic Liver

Authors :
Andraus, Wellington
de Souza, Gabriela Freitas Pereira
de Oliveira, Marcelo Ganzarolli
Haddad, Luciana B.P.
Coelho, Ana Maria M.
Galvão, Flavio Henrique
Leitão, Regina Maria Cubero
D’Albuquerque, Luiz Augusto Carneiro
Machado, Marcel Cerqueira Cesar
Source :
Clinics; January 2010, Vol. 65 Issue: 7 p715-721, 7p
Publication Year :
2010

Abstract

Steatosis is currently the most common chronic liver disease and it can aggravate ischemia-reperfusion (IR) lesions. We hypothesized that S-nitroso-N-acetylcysteine (SNAC), an NO donor component, can ameliorate cell damage from IR injury. In this paper, we report the effect of SNAC on liver IR in rats with normal livers compared to those with steatotic livers.

Details

Language :
English
ISSN :
18075932 and 19805322
Volume :
65
Issue :
7
Database :
Supplemental Index
Journal :
Clinics
Publication Type :
Periodical
Accession number :
ejs59919371
Full Text :
https://doi.org/10.1590/S1807-59322010000700011