PROP1and CTNNB1expression in adamantinomatous craniopharyngiomas with or without β-catenin mutations

Activating mutations in exon 3 of the β-catenin gene are involved in the pathogenesis of adamantinomatous craniopharyngiomas. Recently, the interaction between β-catenin and PROP1 has been shown to be responsible for pituitary cell lineage determination. We hypothesized that dysregulated PROP1expression could also be involved in the pathogenesis of craniopharyngiomas.