Abstract 16275: Cardiac Sarcoidosis: A United States National Study of In-Hospital Outcomes and 30-Day Readmissions

Introduction:Cardiac sarcoidosis (CS) is clinically manifest in 5% of sarcoidosis patients, though up to 25% have subclinical cardiac involvement. Diagnostic advances have improved detection of CS, but much is unknown regarding its optimal management and outcomes.Objective:Using a large national database, we characterized in-hospital outcomes and 30-day readmissions in CS patients.Methods:The 2016 Nationwide Readmissions Database (NRD), accounting for ~36 million discharges in 27 US states with ~58% of the US population, was queried using International Classification of Diseases, 10threvision codes to isolate adult inpatients admitted with CS. Patient characteristics, reasons for hospitalization, diagnostic and therapeutic procedures, in-hospital outcomes, and 30-day readmission causes were collected. Values of interest were counted and their frequencies computed.Results:A total of 1120 patients were included, of whom 1113 had 30-day follow-up data. Mean age was 56 +11 years with 59% male and 51% white subjects. Nearly 77% had a history of heart failure (HF), 46% had ICDs, 8% had PPMs, and 37% had prior chronic kidney disease. The most common causes for hospitalization were arrhythmias (22%) and HF (19%). Sudden cardiac arrest occurred in 1%. While inpatient, ICDs and PPMs were implanted in 6% and 3%, respectively, while 4% underwent catheter ablation and 4% received advanced HF therapies. In 3% of inpatients, CPR was performed, and in-hospital mortality was 1%. In 30-day follow up, unplanned readmission occurred in 28%, with the most common reasons being ventricular tachycardia (16%) and acute heart failure (12%). Nearly 9% had infectious or hematologic causes of readmission.Conclusions:CS hospitalizations are primarily driven by arrhythmic and HF etiologies with an associated high rate of 30-day readmission for similar reasons. Further study is needed to determine if enhanced risk stratification and timely intervention can improve outcomes.