Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Authors :: Doherty, Dearbhla
Lavin, Michelle
Byrne, Mary
Nolan, Margaret
O’Sullivan, Jamie M.
Ryan, Kevin
O’Connell, Niamh M.
Haberichter, Sandra L.
Christopherson, Pamela A.
Di Paola, Jorge
James, Paula D.
O’Donnell, James S.
Montgomery, R.
Flood, V.
Haberichter, S.
Abshire, T.
Weiler, H.
Lillicrap, D.
James, P.
O’Donnell, J.
Ng, C.
Di Paola, J.
Sadler, B.
Abshire, T.
Bennett, C.
Sidonio, R.
Manco-Johnson, M.
Di Paola, J.
Ng, C.
Journeycake, J.
Zia, A.
Lusher, J.
Rajpurkar, M.
Shapiro, A.
Lentz, S.
Gill, J.
Flood, V.
Leissinger, C.
Ragni, M.
Tarantino, M.
Roberts, J.
James, P.
Source :: Blood Advances; February 2023, Vol. 7 Issue: 3 p302-308, 7p
Publication Year :: 2023
Abstract: •Subtle enhanced VWF clearance is present in 20% of patients with low VWF and is associated with an attenuated bleeding phenotype.•In patients with low VWF, there is poor correlation between desmopressin fall-off rates and steady-state VWFpp/VWF:Ag ratios.

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