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Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review

Authors :
Dixon, Padraig
Keeney, Edna
Taylor, Jenny C.
Wordsworth, Sarah
Martin, Richard M.
Source :
Genetics in Medicine; August 2022, Vol. 24 Issue: 8 p1604-1617, 14p
Publication Year :
2022

Abstract

Polygenic risk influences susceptibility to cancer. We assessed whether polygenic risk scores could be used in conjunction with other predictors of future disease status in cost-effective risk-stratified screening for cancer.

Details

Language :
English
ISSN :
10983600 and 15300366
Volume :
24
Issue :
8
Database :
Supplemental Index
Journal :
Genetics in Medicine
Publication Type :
Periodical
Accession number :
ejs59500484
Full Text :
https://doi.org/10.1016/j.gim.2022.04.020