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Griseocazines: Neuroprotective Multiprenylated Cyclodipeptides Identified through Targeted Genome Mining
- Source :
- Organic Letters; April 2022, Vol. 24 Issue: 16 p2967-2972, 6p
- Publication Year :
- 2022
-
Abstract
- Prenylation can impart pharmacological advantages to bioactive compounds. Global genome mining for prenylated cyclodipeptides identified a gczABCBGC from Streptomyces griseocarneus132 containing a cyclodipeptide synthase and two prenyltransferase genes. Subsequent heterologous expression allowed isolation and characterization of griseocazines, which displayed potent neuroprotective activity. Further biotransformation analyses revealed that prenyltransferases GczB and GczC catalyzed the stereospecific prenylation of cWW and attached geranyl and farnesyl groups to a cyclodipeptide scaffold, respectively.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 24
- Issue :
- 16
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs59459076
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c00745