Back to Search Start Over

Electrochemical Estimations of the Gold Nanoparticle Size Effect on Cysteine-Gold Oxidation

Authors :
Romanovskaia, Elena
Slovenský, Peter
Kalantarian, S. Marzieh
Laundry-Mottiar, Lila
Romanovski, Valentin
Halama, Maroš
Auinger, Michael
Hedberg, Yolanda S.
Source :
Journal of the Electrochemical Society; February 2022, Vol. 169 Issue: 2 p021501-021501, 1p
Publication Year :
2022

Abstract

Gold nanoparticles are interesting for nanobiomedical applications, such as for drug delivery and as diagnostic imaging contrast agents. However, their stability and reactivity in-vivo are influenced by their surface properties and size. Here, we investigate the electrochemical oxidation of differently sized citrate-coated gold nanoparticles in the presence and absence of L-cysteine, a thiol-containing amino acid with high binding affinity to gold. We found that smaller sized (5, 10 nm) gold nanoparticles were significantly more susceptible to electrochemical L-cysteine interactions and/or L-cysteine-facilitated gold oxidation than larger (20, 50 nm) sized gold nanoparticles, both for the same mass and nominal surface area, under the conditions investigated (pH 7.4, room temperature, stagnant solutions, and scan rates of 0.5 to 450 mV s−1). The electrochemical measurements of drop-casted gold nanoparticle suspensions on paraffin-impregnated graphite electrodes were susceptible to the quality of the electrode. Increased cycling resulted in irreversible oxidation and detachment/oxidation of gold into solution. Our results suggest that L-cysteine-gold interactions are stronger for smaller nanoparticles.

Details

Language :
English
ISSN :
00134651 and 19457111
Volume :
169
Issue :
2
Database :
Supplemental Index
Journal :
Journal of the Electrochemical Society
Publication Type :
Periodical
Accession number :
ejs59349027
Full Text :
https://doi.org/10.1149/1945-7111/ac4bf8