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A Quantitative Bioassay to Determine the Inhibitory Potency of NGF–TrkA Antagonists
- Source :
- SLAS Discovery: Advancing Life Sciences R&D; July 2021, Vol. 26 Issue: 6 p823-830, 8p
- Publication Year :
- 2021
-
Abstract
- In this article, we demonstrate and validate a new bioassay named the NTAB [NGF–TrkA (nerve growth factor–tropomyosin receptor kinase A) antagonist bioassay] for the determination of the inhibitory potency of NGF–TrkA antagonists, based on the inhibition of NGF-dependent proliferation of the human TF1 erythroleukemic cell line.
Details
- Language :
- English
- ISSN :
- 24725552 and 24725560
- Volume :
- 26
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- SLAS Discovery: Advancing Life Sciences R&D
- Publication Type :
- Periodical
- Accession number :
- ejs59201188
- Full Text :
- https://doi.org/10.1177/24725552211000672