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Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial

Authors :
Shah, Sanjiv J
Borlaug, Barry A
Chung, Eugene S
Cutlip, Donald E
Debonnaire, Philippe
Fail, Peter S
Gao, Qi
Hasenfuß, Gerd
Kahwash, Rami
Kaye, David M
Litwin, Sheldon E
Lurz, Philipp
Massaro, Joseph M
Mohan, Rajeev C
Ricciardi, Mark J
Solomon, Scott D
Sverdlov, Aaron L
Swarup, Vijendra
van Veldhuisen, Dirk J
Winkler, Sebastian
Leon, Martin B
Akar, Joseph
Ando, Jiro
Anzai, Toshihisa
Asakura, Masanori
Bailey, Steven
Basuray, Anupam
Bauer, Fabrice
Bergmann, Martin
Blair, John
Cavendish, Jeffrey
Chung, Eugene
Cikes, Maja
Dauber, Ira
Donal, Erwan
Eicher, Jean-Christophe
Fail, Peter
Flaherty, James
Freixa, Xavier
Gafoor, Sameer
Gertz, Zachary
Gordon, Robert
Guazzi, Marco
Guerrero-Miranda, Cesar
Gupta, Deepak
Gustafsson, Finn
Hadadi, Cyrus
Hakemi, Emad
Handoko, Louis
Hass, Moritz
Hausleiter, Jorg
Hayward, Christopher
Hickey, Gavin
Hummel, Scott
Hussain, Imad
Isnard, Richard
Izumi, Chisato
Jondeau, Guillaume
Juneman, Elizabeth
Kinugawa, Koichiro
Kipperman, Robert
Krakowiak, Bartek
Krim, Selim
Larned, Joshua
Lewis, Gregory
Lipsic, Erik
Magalski, Anthony
Mazimba, Sula
Mazurek, Jeremy
McGrady, Michele
Mckenzie, Scott
Mehta, Shamir
Mignone, John
Morsli, Hakim
Nair, Ajith
Noel, Thomas
Orford, James
Parikh, Kishan
Patterson, Tiffany
Penicka, Martin
Petrie, Mark
Pieske, Burkert
Post, Martijn
Raake, Philip
Romero, Alicia
Ryan, John
Saito, Yoshihiko
Sakamoto, Takafumi
Sakata, Yasushi
Samara, Michael
Satya, Kumar
Sindone, Andrew
Starling, Randall
Trochu, Jean-Noël
Upadhya, Bharathi
van der Heyden, Jan
van Empel, Vanessa
Varma, Amit
Vest, Amanda
Wengenmayer, Tobias
Westenfeld, Ralf
Westermann, Dirk
Yamamoto, Kazuhiro
Zirlik, Andreas
Source :
The Lancet; March 2022, Vol. 399 Issue: 10330 p1130-1140, 11p
Publication Year :
2022

Abstract

Placement of an interatrial shunt device reduces pulmonary capillary wedge pressure during exercise in patients with heart failure and preserved or mildly reduced ejection fraction. We aimed to investigate whether an interatrial shunt can reduce heart failure events or improve health status in these patients.

Details

Language :
English
ISSN :
01406736 and 1474547X
Volume :
399
Issue :
10330
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs59183736
Full Text :
https://doi.org/10.1016/S0140-6736(22)00016-2