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The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

Authors :
Tiddens, Harm A W M
Chen, Yuxin
Andrinopoulou, Eleni-Rosalina
Davis, Stephanie D
Rosenfeld, Margaret
Ratjen, Felix
Kronmal, Richard A
Hinckley Stukovsky, Karen D
Dasiewicz, Alison
Stick, Stephen Michael
Andrinopoulou, Eleni-Rosalina
Anthony, Margaret M.
Au, Jacky
Belessis, Yvonne
Bonte, Merlijn
Chen, Yuxin
Cheney, Joyce
Clem, Charles
Clements, Barry
Cooper, Peter
Dasiewicz, Alison
Davis, Stephanie D.
Davis, Miriam
de Boeck, Kris
de Marchis, Matteo
De Wachter, Elke
Delaisi, Bertrand
Delaup, Véronique
DeRicco, Adrienne
Foti, Alexia
Gan, Richard
Garriga, Laura
Gartner, Silvia
Genatossio, Alan
Grogan, Sam
Hilton, Jodi
Hinckley Stukovsky, Karen D
Hoppe, Jordana E.
Janssens, Hettie M.
Jensen, Renee
Johnson, Robin
Kemner-van de Corput, Mariette P.C.
Klein, Brendan
Kronmal, Richard A.
Lucca, Francesca
Lucidi, Vincencina
Montemitro, Enza
Nahidi, Lily
Nielsen, Kim G.
Pearce, Kasey
Pittman, Jessica E
Powers, Michael
Prentice, Carley
Pressler, Tania
Ratjen, Felix
Rayment, Jonathan H
Reix, Philippe
Retsch-Bogart, George
Riera, Luis
Robinson, Phil
Robinson, Paul
Rosenfeld, Margaret
Sanders, Don B.
Sandoval, Rodrigo A.
Sandvik, Rikke Mulvad
Saunders, Clare
Siegel, Molly
Smith, Julie
Solomon, Melinda
Stanojevic, Sanja
Stick, Stephen Michael
Tai, Andrew
Tiddens, Harm A.W.M.
van de Puttelaar, Jorien
Van den Brande, Christel
van Straten, Marcel
Vermeulen, Francois
Volpi, Sonia
Wainwright, Claire E.
Weiner, Daniel J.
Yuan, Yi
Zaimeddine, Sarah
Source :
The Lancet Respiratory Medicine; July 2022, Vol. 10 Issue: 7 p669-678, 10p
Publication Year :
2022

Abstract

In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7% hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic fibrosis, but it remained unclear whether improvement is also seen in structural lung disease. We aimed to assess the effect of inhaled hypertonic saline on chest CT imaging in children aged 3–6 years with cystic fibrosis.

Details

Language :
English
ISSN :
22132600 and 22132619
Volume :
10
Issue :
7
Database :
Supplemental Index
Journal :
The Lancet Respiratory Medicine
Publication Type :
Periodical
Accession number :
ejs59141744
Full Text :
https://doi.org/10.1016/S2213-2600(21)00546-4